Incorporation of 5-substituted uracil derivatives into nucleic acids. Part IV. The synthesis of 5-ethynyluracil
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چکیده
منابع مشابه
Uptake and Incorporation of Thymine, Thymidine, Uracil, Uridine, and 5-fluorouracil into the Nucleic Acids of Bacillus Subtilis.
Bodmer, Walter F. (Stanford University School of Medicine, Palo Alto, Calif.), and Susan Grether. Uptake and incorporation of thymine, thymidine, uracil, uridine, and 5-fluorouracil into the nucleic acids of Bacillus subtilis. J. Bacteriol. 89:1011-1014. 1965.-From 55 to 95% of uracil, uridine, or 5-fluorouracil (FU) added to the culture medium is incorporated into the acid-insoluble fraction o...
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A stereoselective radical-mediated hydrogermylation of the protected 5-ethynyluracil nucleosides with trialkyl-, triaryl,- or tris(trimethylsilyl)germanes gave (Z)-5-(2-germylvinyl)uridine, 2'-deoxyuridine, or ara-uridine as major products. Reaction of the β-triphenylgermyl vinyl radical intermediate with oxygen and fragmentation of the resulting peroxyradical provided also 5-[2-(triphenylgermy...
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3-Arylhydrazono-2,4-dioxo-4-phenylbutanoateshave been prepared by the coupling of benzoylpyruvate with aryldiazonium chlorides.Reactions ofthe 3-arylhydrazono-2,4-dioxo-4-phenylbutanoateswith 1-aminoguanidine, semicarbazide, and thiosemicarbazidegave5-substituted 2-imino-6-azauracil (3a),6-azauracil (3b), and 2-thio-6-azauracil (3c), respectively. The analytical data of these compounds - IR, 1H...
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The tumor growth-inhibitor 6-diazo-5-oxo-L-norleucine (DOX) was shown to inhibit, from 90 to 98 per cent, the incorporation of formate-C14 into the purine bases of the nucleic acids from Sarcoma 180 tissue, small intestine, and liver, when given at the same time as the precursor formate. The inhibition was less, but still substantial, when the DOX was given in small multiple doses instead of a ...
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The pyrimidine-deficient mutant (1298) of Neurospora crassa, utilizes erotic acid, uracil, uridine, or cytidine for growth, but neither cytosine nor thymine (1). It seems likely, therefore, that this mutant can convert erotic acid and uracil to the pyrimidine bases of ribonucleic acid and deoxyribonucleic acid, and can utilize the nucleoside directly for ribonucleic acid biosynthesis and for co...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1976
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/3.10.2845